Achieve steady flow for critical bioprocesses
Positive displacement pumps, such as peristaltic and diaphragm models, introduce unwanted pulsations into the fluid stream. These flow irregularities create instability that can critically compromise sensitive, single-use processes like Tangential Flow Filtration (TFF) and chromatography, which demand absolute control over flow rates and line pressures. The CPC Biotech single-use dampener is engineered to precisely counter this, effectively reducing pulsation and flow variance to ensure the integrity of critical biopharmaceutical media during processing and transfer applications.
Flow stability and process control
PSG Biotech single-use dampeners are the essential safeguard against flow inconsistencies, actively mitigating the pressure and velocity variations inherent to positive displacement pumps. This crucial stabilization ensures the absolute integrity of critical biopharmaceutical media, enabling highly controlled and optimized performance across all sensitive processing and transfer applications.
Material purity and compliance
PSG Biotech dampeners are manufactured with all-plastic wetted surfaces to ensure the highest level of product purity and compliance. These molded designs meet stringent regulatory standards, including USP Class VI, USP 661.2, and USP 788 requirements. Furthermore, the inherent smoothness of the design minimizes fluid shear, and the unit is certified gamma stable up to 50 kGy for seamless integration into sterile bioprocessing workflows.
Principal of operation
Positioned immediately downstream of the positive displacement pump, the fluid enters the DMP-7000 where its flexible polyurethane-membraned chambers instantly activate. These specialized chambers efficiently absorb the pressure waves and flow irregularities generated by the pump’s operation, resulting in a continuous, stabilized flow and consistent pressure rate downstream.
Key performance and design advantages:
- Up to 95% reduction in peak-to-peak flow pulsation
- Wetted fluid path materials (Polyurethane and PEEK) meet USP Class VI, USP 661.2, and USP 788 requirements
- Gamma-stable to 50 kGy for seamless sterile integration
- Patent-pending single-use design eliminates flow rate and line pressure pulsation.
- Pressure rating up to 90 psi (6 bar)
- Available for line sizes from 1/4" to 1" ID, with hose barb or triclamp fluid connections
Application versatility
The PSG Biotech DMP-7000 Pulsation Dampener is critical for sensitive biopharmaceutical processes where stable flow is mandatory. Its primary applications include Tangential Flow Filtration (TFF) and Chromatography, where it ensures precise flow rates and pressure stability to protect expensive media and optimize separation efficiency. Furthermore, it is essential in high-accuracy operations like Filling and general Fluid Transfer, guaranteeing consistent dosing and protecting downstream instrumentation. By stabilizing the output of positive displacement pumps, the DMP-7000 ensures continuous, validated, and highly controlled bioprocessing workflows.