- a monitoring tool for general anesthesia
Due to pharmacokinetics, there is a time delay in agent concentration between the end-tidal MAC and the target organ. MAC Brain, available with Flow anaesthesia machines, visualizes the difference to support better dosing and planning of agent delivery.
Potential use areas for MAC Brain
Discussions with early adopters of MAC Brain has identified the following uses:
- Provides more information when monitoring the depth of anesthesia, especially during induction and emergence.
- Provides additional information when the patient may be at risk of over or underdosing.
The chart illustrates what early adopters answered when asked about the benefits they experienced with MAC Brain during surgery. 
How MAC Brain works
The image shows the interface of the Flow-i anesthesia machine. The end-tidal MAC and MAC brain are found in the lower left corner of the screen (marked with a green frame). The interface snapshot was taken during induction, when the difference between the two values is often the highest.
MAC Brain is visualized on screen using an algorithm based on basic research and pharmacokinetic models. The option is included in the 4.7 software and is easily brought forward and removed from the menu when needed.
More unique innovations for our anesthesia machines
With our flow anesthesia technology you can easily ensure the perfect flow for each patient, finetuning anaesthesia delivery in real time, breath by breath.
Flow-i anesthesia machine
- our intelligent model
Flow-i is the intelligent workstation, a highly advanced anesthesia machine offering superior ventilation performance, decision support features, a wider range of settings of flows and pressures, and the innovative AGC option. Flow-i provides safe, personalized and cost-efficient care,also for the most challenging patients. Available in three versions, it’s a dynamic solution, including a heightadjustable model, and a pendant model suspended from the ceiling.
Flow-e anesthesia machine
- our extended model
Flow-e is the extended, flexible workstation for dynamic anesthesia delivery. Featuring Getinge’s proprietary innovations, the machine ensures safe, personalized care for a wide range of patients. With a larger worktop, more storage space, and generous mounting possibilities for auxiliary equipment, Flow-e can be customized to match your needs and preference in safe treatment for patients.
Flow-c anesthesia machine
- our compact model
Flow-c is the compact, easy-to-use dynamic workstation, enabling safe and cost-efficient treatment. The compact design is an advantage in a crowded OR with a busy schedule. Despite its small size, it has Flow Family advantages such as ventilation performance to ICU standards, precision agent dosing, hypoxia prevention technologies, an intuitive user interface, and several mounting possibilities.
Drews FA, Syroid N, Agutter J, Strayer DL, Westenskow DR. Drug delivery as control task: improving performance in common anesthetic task. Hum Factors 2006;48:85–94.
Ross Kennedy, Margie McKellow, Richard French, Jamie Sleigh. Sevoflurane End-Tidal to Effect-Site Equilibration in Women Determined by Response to Laryngeal Mask Airway Insertion. Anesth Analg 2013;117:786–91
Internal report EVU-197031 - 01 - Flow 4.7 Enhanced Post Market Surveillance Report 2019
Internal report EVU-194160 - User evaluation EPMS Flow 4.7 2019