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Tecnologia CeVOX

CeVOX Module for CeVOX Technology
cevox technology

Tecnologia CeVOX

Monitoraggio continuo della saturazione di ossigeno venosa centrale

La tecnologia CeVOX utilizza il metodo della spettrofotometria

Panoramica

ScvO2 offre un'informazione rapida sullo stato emodinamico del paziente ScvO2 è molto più sensibile rispetto alla pressione sanguigna e alla frequenza cardiaca per rilevare lo stato di shock di qualsiasi origine.

Accessori generali

Il monitoraggio ScvO2   facilita il rilevamento precoce dei seguenti parametri:

  • Squilibrio tra apporto e consumo di ossigeno [2]
  • Stato di shock di qualsiasi origine [1]
  • Gittata cardiaca insufficiente (parametro surrogato) [3]

Vantaggi

  • Riconoscimento immediato dell'ossigenazione tissutale insufficiente [4], [5]
  • Accesso tramite CVC standard
  • Riduzione dell'emogasanalisi [6]
  • Bilancio dell'ossigeno in tempo reale
  • Facile manipolazione, nessuna calibrazione in vitro richiesta

Applicazione utile in

Articoli monouso

Sonda CeVOX

  • Ossimetria continua a fibre ottiche
  • Applicazione confortevole
  • Accesso tramite CVC standard esistente
  • Facile collocamento
  • ScvO2 immediatamente disponibile


Le sonde CeVOX  possono essere inserite nel lume distale di CVC di 15, 20 o 30 cm che consentono l'utilizzo di fili guida ≥0,032".

Metodologia

La spettrofotometria è la misurazione quantitativa delle proprietà di riflessione o trasmissione di un materiale in funzione delle lunghezze d'onda della luce. La tecnologia CeVOX usa questo metodo per misurare la saturazione di ossigeno del sangue in modo continuo. A questo scopo, una sonda CeVOX con fibre ottiche incorporate viene inserita in un vaso sanguigno, di solito una vena centrale.

Un modulo ottico emette luce a infrarossi di specifiche lunghezze d'onda e la trasmette attraverso una fibra ottica nel vaso. La luce viene riflessa dai globuli rossi e ritrasmessa attraverso una fibra ottica separata nel modulo ottico e analizzata da un sensore.

Bibliografia

Tanczos K & Molnar Z  
The oxygen supply-demand balance: A monitoring challenge  
Best Pract Res Clin Anaesthesiol 2013; 27(2): 201-7 

Ducrocq N, Kimmoun A, Levy B  
LACTATE or ScvO2 as an endpoint in resuscitation of shock states?  
Minerva Anestesiol 2013; 79(9): 1049-58 

Reid M  
Central venous oxygen saturation: analysis, clinical use and effects on mortality  
Nurs Crit Care 2013; 18(5): 245-50 

Walley KR.  
Use of Central Venous Oxygen Saturation to Guide Therapy  
Am J Respir Crit Care Med 2011;184:514-20 

Bauer P, Reinhart K, Bauer M.  
Early goal directed therapy and outcome in septic shock  
Int J Intensive Care 2007; Autumn:19-24 

Marx G, Reinhart K.  
Venous oximetry  
Curr Opin Crit Care 2006; 12:263-8 

Goodrich C.  
Continuous central venous oximetry monitoring  
Crit Care Nurs Clin North Am 2006; 18:203-9 

Rivers EP, Ander DS, Powell D.  
Central venous oxygen saturation monitoring in the critically ill patient  
Curr Opin Crit Care 2001; 7:204-11 

Recensione

Tanczos K & Molnar Z
The oxygen supply-demand balance: A monitoring challenge
Best Pract Res Clin Anaesthesiol 2013; 27(2): 201-7

Convalida CeVOX

Molnar Z, Umgelter A, Toth I, Livingstone D, Weyland A, Sakka SG, Meier-Hellmann A.
Continuous monitoring of ScvO(2) by a new fibre-optic technology compared with blood gas oximetry in critically ill patients: a multicentre study
Intensive Care Med 2007; 33(10): 1767-70

Shock settico

Maddirala S and Khan A
Optimizing hemodynamic support in septic shock using central and mixed venous oxygen saturation
Crit Care Clin 2010; 26(2): 323-33

Rivers ER, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M.
Early goal-directed therapy in the treatment of severe sepsis and septic shock
N Eng J Med 2001; 345:1368–77

 

ScvO2 vs. SvO2 

el-Masry A, Mukhtar MA, el-Sherbeny AM, Fathy M, el-Meteini M  
Comparison of central venous oxygen saturation and mixed venous oxygen saturation during liver transplantation  
Anaesthesia 2009; 64(4): 378-82 

Kopterides P, Bonovas S, Mavrou I, Kostadima E, Zakynthinos E, Armaganidis AS.  
Venous Oxygen Saturation and Lactate Gradient from Superior Vena Cava to Pulmonary Artery in Patients with Septic Shock  
Shock 2009; 31(6): 561-7 

Sander M, Spies CD, Foer A, Weymann L, Braun J, Volk T, Grubitzsch H, von Heymann C.
Agreement of central venous saturation and mixed venous saturation in cardiac surgery patients 
Intensive Care Med 2007; 33(10): 1719-25 

Reinhart K, Kuhn HJ, Hartog C, Bredle DL.  
Continuous central venous and pulmonary artery oxygen saturation monitoring in the critically ill  
Curr Opin Crit Care 2004; 30:1572-8 

Ladakis C, Myrianthefs P, Karabinis A, Karatzas G, Dosios T, Fildissis G, Gogas J, Baltopoulos G.  
Central venous and mixed venous oxygen saturation in critically ill patients 
Respiration 2001; 68:279-85 

ScvO2 continua 

Hofer CK, Ganter M, Fodor P, Tavakoli R, Genoni M, Zollinger A.  
Continuous central venous oxygenation measurement by CeVOX in patients undergoing off-pump coronary bypass grafting  
Crit Care 2006:P340 

Rivers ER, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M.  
Early goal-directed therapy in the treatment of severe sepsis and septic shock  
N Eng J Med 2001; 345:1368–7 

Rady MY, Rivers EP, Martin GB, Smithline H, Appelton T, Nowak RM.  
Continuous central venous oximetry and shock index in the emergency department: use in the evaluation of clinical shock  
Am J Emerg Med 1992; 10:538-41 

Molnar Z, Umgelter A, Toth I, Livingstone D, Weyland A, Sakka SG, Meier-Hellmann A. 
Continuous monitoring of ScvO(2) by a new fibre-optic technology compared with blood gas oximetry in critically ill patients: a multicentre study  
Intensive Care Med 2007; 33(10): 1767-70 

Muller M, Lohr T, Scholz S, Thul J, Akinturk H, Hempelmann G.  
Continuous SvO(2) measurement in infants undergoing congenital heart surgery - first clinical experiences with a new fiberoptic probe 
Paediatr Anaesth. 2007; 17(1):51-5. Feb 

Ducart A, Dejonckheere M, Koch M, Perrin L, Schmartz D.  
Continuous central venous and pulmonary artery oxygen saturation monitoring in cardiac surgery after cardiopulmonary bypass  
Eur J Anaesthesiol 2007; 4AP2-7 

Huber D, Osthaus W, Optenhöfel J, Breymann T, Marx G, Piepenbrock S, Sümpelmann R. 
Continuous monitoring of central venous oxygen saturation in neonates and small infants: in vitro evaluation of two different oximetry catheters  
Paediatr Anaesth 2006; 16(12):1257-61 

Hofer CK, Ganter M, Fodor P, Tavakoli R, Genoni M, Zollinger A.  
Continuous central venous oxygenation measurement by CeVOX in patients undergoing off-pump coronary bypass grafting  
Crit Care 2006:P340 

Confronto costi ScvO2 ed Emogasanalisi 

Bloos F, Rissner F, Specht M, Reinhart K, Marx G  
Costs of intermittent measurement of central venous oxygen saturations by blood gas analysis  
Intensive Care Med 2009; 35(7): 1316-7 

Pubblicazioni

Outcome e linee guida

Linee guida e procedure operative standard

Reinhart K, Brunkhorst FM et al. [Prevention, diagnosis, treatment, and follow-up care of sepsis. Prima revisione di 
S2k Guidelines of the German Sepsis Society (DSG) and the German Interdisciplinary Association for Intensive and Emergency Care Medicine (DIVI)]. 
Ger Med Sci 2010; Doc 14

Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, Reinhart K, Angus DC, Brun-Buisson C, Beale R, Calandra T, Dhainaut JF, Gerlach H, Harvey M, Marini JJ, Marshall J, Ranieri M, Ramsay G, Sevransky J, Thompson BT, Townsend S, Vender JS, Zimmerman JL, Vincent JL. 
Surviving Sepsis Campaign Linee guida internazionali per il trattamento di sepsi severa e shock settico: 2008 
Intensive Care Med 2008; 34(1): 17-60

De Oliveira CF, de Oliveira DS, Gottschald AF, Moura JD, Costa GA, Ventura AC, Fernandes JC, Vaz FA, Carcillo JA, Rivers EP, Troster EJ. 
ACCM / PALS haemodynamic support guidelines for paediatric septic shock: an outcomes comparison with and without monitoring central venous oxygen saturation
ICM 2008; 34 (6): 1065-75

Carl M, Alms A, Braun J, Dongas A, Erb J, Goetz A, Goepfert M, Gogarten W, Grosse J, Heller A, Heringlake M, Kastrup M, Kroener A, Loer S, Marggraf G, Markewitz A, Reuter M, Schmitt DV, Schirmer U, Wiesenack C, Zwissler B, Spies C. 
S3 Guidelines for Intensive Care in Cardiac Surgery Patients: Monitoraggio emodinamico e sistema circolatorio 
Ger Med Sci 2010; 8: Doc 12

Trzeciak S, Dellinger RP, Abate NL, Cowan RM, Stauss M, Kilgannon JH, Zanotti S, Parrillo JE. 
Translating research to clinical practice: a 1-year experience with implementing early goal-directed therapy for septic shock in the emergency department 
Chest 2006; 129:225-32

Articoli sui risultati

Smetkin AA, Kirov M, Kuzkov VV, Lenkin AI, Eremeev AV, Slastilin VY, Borodin VV, Bjertnaes LJ. 
Single transpulmonary thermodilution and continuous monitoring of central venous oxygen saturation during off-pump coronary surgery. 
Acta Anaesthesiol Scand 2009; 53:505-14

Csontos C, Foldi V, Fischer T, Bogar L. 
Arterial thermodilution in burn patients suggests a more rapid fluid administration during early resuscitation. 
Acta Anaesthesiol Scand 2008; 52(6): 742-9

de Oliveira CF, de Oliveira DS, Gottschald AF, Moura JD, Costa GA, Ventura AC, Fernandes JC, Vaz FA, Carcillo JA, Rivers EP, Troster EJ. 
ACCM/PALS haemodynamic support guidelines for paediatric septic shock: an outcomes comparison with and without monitoring central venous oxygen saturation.
Intensive Care Med 2008; 34(6): 1065-75.

Kortgen A, Niederprün P, Bauer M. 
Implementation of an evidence-based „standard operating procedure“ and outcome in septic shock 
Crit Care Med 2006; 34(4):943-9

Rivers ER, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M. 
Early goal-directed therapy in the treatment of severe sepsis and septic shock 
N Eng J Med 2001; 345:1368–7

Uso clinico Shock settico

Maddirala S and Khan A 
Optimizing hemodynamic support in septic shock using central and mixed venous oxygen saturation 
Crit Care Clin 2010; 26(2): 323-33

Pope JV, Jones AE, Gaieski DF, Arnold RC, Trzeciak S, Shapiro NI
Multicenter Study of Central Venous Oxygen Saturation (ScvO(2)) as a Predictor of Mortality in Patients With Sepsis 
Ann Emerg Med 2010; 55(1): 40-6

Nguyen HB, Corbett SW, Steele R, Banta J, Clark RT, Hayes SR, Edwards J, Cho TW, Wittlake WA. 
Implementation of a bundle of quality indicators for the early management of severe sepsis and septic shock is associated with decreased mortality 
Crit Care Med 2007; 35 (4): 1105-12

Kortgen A, Niederprün P, Bauer M. 
Implementation of an evidence-based „standard operating procedure“ and outcome in septic shock 
Crit Care Med 2006; 34(4):939-9

Trzeciak S, Dellinger RP, Abate NL, Cowan RM, Stauss M, Kilgannon JH, Zanotti S, Parrillo JE. 
Translating research to clinical practice: a 1-year experience with implementing early goal-directed therapy for septic shock in the emergency department 
Chest 2006;129: 225-32

Rivers ER, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M. 
Early goal-directed therapy in the treatment of severe sepsis and septic shock 
N Eng J Med 2001; 345:1368–77

Shock Cardiogeno e Rianimazione Cardiopolmonare

Chin K, Channick RN, Kim NH, Rubin LJ. 
Central venous blood oxygen saturation monitoring in patients with chronic pulmonary arterial hypertension treated with continuous IV epoprostenol: correlation with measurements of hemodynamics and plasma brain natriuretic peptide levels.
Chest 2007; 132(3): 786-92.

Ander DS, Jaggi M, Rivers E, Rady MY, Levine TB, Levine AB, Masura J, Gryzbowski M.
Undetected cardiogenic shock in patients with congestive heart failure presenting to the emergency department 
Am J Cardiol 1998; 82:888-91

Rivers EP, Martin GB, Smithline H, Rady MY, Schultz CH, Goetting MG, Appleton TJ, Nowak RM. 
The clinical implications of continuous central venous oxygen saturation during human CPR 
Ann Emerg Med 1992; 21:1094-1101

Rivers EP, Rady MY, Martin GB, Fenn NM, Smithline HA, Alexander ME, Nowak RM.
Venous hyperoxia after cardiac arrest. Caratterizzazione di un'anomalia nell'utilizzo di ossigeno sistemico 
Torace. 1992; 102(6):1787-93

Cardiochirurgia

Hu BY, Laine GA, Wang S, Solis RT 
Combined central venous oxygen saturation and lactate as markers of occult hypoperfusion and outcome following cardiac surgery 
J Cardiothorac Vasc Anesth 2012; 26(1): 52-7.

Perz S, Uhlig T, Kohl M, Bredle DL, Reinhart K, Bauer M, Kortgen A. 
Low and "supranormal" central venous oxygen saturation and markers of tissue hypoxia in cardiac surgery patients: a prospective observational study. 
Intensive Care Med 2011; 1: 52-9

Nogueira PM, Mendonca-Filho MT, Campos LA, Gomes RV, Felipe AR, Fernandes MA, Villela-Nogueira CA, Rocco JR. 
Central Venous Saturation: A Prognostic Tool in Cardiac Surgery Patients 
J Intensive Care Med 2010; 25(2): 111-6

Smetkin AA, Kirov M, Kuzkov VV, Lenkin AI, Eremeev AV, Slastilin VY, Borodin VV, Bjertnaes LJ. 
Single transpulmonary thermodilution and continuous monitoring of central venous oxygen saturation during off-pump coronary surgery. 
Acta Anaesthesiol Scand 2009; 53: 505-14

Chirurgia generale

Meguro M, Mizuguchi T, Kawamoto M, Nakamura Y, Ota S, Kukita K, Ishii M, Tatsumi H, Hirata K 
Continuous monitoring of central venous oxygen saturation predicts postoperative liver dysfunction after liver resection 
Surgery 2013; 15482): 351-62

Jakob S. 
Multicentre study on peri-postoperative central venous oxygen saturation in high-risk surgical patients 
Critical Care 2006; 10:R158

Pearse R, Dawson D, Fawcett J, Rhodes A, Grounds RM, Bennett ED.
Changes in central venous saturation after major surgery, and association with outcome 
Crit Care 2005; 9:R694-9

Pediatria

de Oliveira CF, de Oliveira DS, Gottschald AF, Moura JD, Costa GA, Ventura AC, Fernandes JC, Vaz FA, Carcillo JA, Rivers EP, Troster EJ. 
ACCM/PALS haemodynamic support guidelines for paediatric septic shock: an outcomes comparison with and without monitoring central venous oxygen saturation.
Intensive Care Med 2008; 34(6): 1065-75.

Seear MD, Scarfe JC, Leblanc JG. 
Predicting major adverse events after cardiac surgery in children 
Pediatr Crit Care Med 2008; 9(6): 606-11

Muller M, Lohr T, Scholz S, Thul J, Akinturk H, Hempelmann G. 
Continuous SvO(2) measurement in infants undergoing congenital heart surgery - first clinical experiences with a new fiberoptic probe 
Paediatr Anaesth. 2007; 17(1):51-5.

Osthaus WA, Huber D, Beck C , Roehler A, Marx G, Hecker H, Sümpelmann R. 
Correlation of oxygen delivery with central venous oxygen saturation, mean arterial pressure and heart rate in piglets 
Paediatr Anaesth. 2006; 16(9):944-7.

Huber D, Osthaus W, Optenhöfel J, Breymann T, Marx G, Piepenbrock S, Sümpelmann R.
Continuous monitoring of central venous oxygen saturation in neonates and small infants: in vitro evaluation of two different oximetry catheters 
Paediatr Anesth. 2006; 16(12):1257-61

ScvO2 come indicatore per trasfusione di sangue

Krantz T, Warberg J, Secher NH. 
Venous oxygen saturation during normovolaemic haemodilution in the pig 
Acta Anaesthesiol Scand 2005; 49:1149-56

Schou H, Perez de Sa V, Larsson A. 
Central and mixed venous blood oxygen correlate well during acute normovolemic hemodilution in anesthetized pigs 
Acta Anaesthesiol Scand 1998; 42:172-7

Ustioni

Csontos C, Foldi V, Fischer T, Bogar L. 
Arterial thermodilution in burn patients suggests a more rapid fluid administration during early resuscitation. 
Acta Anaesthesiol Scand 2008; 52(6): 742-9

Medico

Giraud R, Siegenthaler N, Gayet-Ageron A, Combescure C, Romand JA, Bendjelid K.
ScvO2 As a Marker to Define Fluid Responsiveness 
J Trauma 2011;70(4): 802-7

Jansen TC, van Bommel J, Schoonderbeek J, Sleeswijk Visser SJ, van der Klooster JM, Lima AP, Willemsen SP, Bakker J 
Early Lactate-Guided Therapy in ICU Patients: A Multicenter, Open-Label, Randomized, Controlled Trial. 
Am J Respir Crit Care Med 2010; 182: 752-61

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Piattaforma modulare con visualizzazione intelligente per il monitoraggio avanzato del paziente

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Monitoraggio non invasivo della funzione epatica o della perfusione splancnica

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Tecnologia NICCI

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Riferimenti

  1. Rady MY et al. Resuscitation of the critically ill in the ED: responses of blood pressure, heart rate, shock index, central venous oxygen saturation, and lactate.
    Am J Emerg Med. 1996 Mar;14(2):218-25.
    DOI: 10.1016/s0735-6757(96)90136-9
    **Nature of the claim: Similar device

  2. Reinhart K et al. Continuous central venous and pulmonary artery oxygen saturation monitoring in the critically ill. Intensive Care Med (2004) 30:1572–1578.
    DOI: 10.1007/s00134-004-2337-y
    *Nature of the claim: General, not product specific.

  3. Müller T et al. Das Monitoring der zentralvenösen und gemischtvenösen Sauerstoffsättigung. Intensivmed 2003, 40:711–719.
    DOI 10.1007/s00390-003-0385-0
    *Nature of the claim: General, not product specific.

  4. Perz S et al. Low and ‘‘supranormal’’ central venous oxygen saturation and markers of tissue hypoxia in cardiac surgery patients: a prospective observational study. Intensive Care Med 2011; 37:52–59. DOI 10.1007/s00134-010-1980-8
    **Nature of the claim: Similar device

  5. Marx G, Reinhart K, Venous oximetry. Curr Opin Crit Care 2006; 12:263–268. DOI: 10.1097/01.ccx.0000224872.09077.dc
    **Nature of the claim: Similar device


  6. Bloos F et al. Costs of intermittent measurement of central venous oxygen saturations by blood gas analysis. Intensive Care Med 2009 Jul;35(7):1316-7.
    DOI 10.1007/s00134-009-1407-6
    *Nature of the claim: General, not product specific.

  7. Trzeciak S et al. A 1-Year Experience With Implementing Early Goal-Directed Therapy for Septic Shock in the Emergency Department. Chest 2006 Feb;129(2):225-32.
    DOI: 10.1378/chest.129.2.225
    **Nature of the claim: Similar device

  8. Rivers et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001; Nov 8;345(19):1368-77. DOI: 10.1056/NEJMoa010307
    **Nature of the claim: Similar device

  9. Park JH et al. Prognostic Value of Central Venous Oxygen Saturation and Blood Lactate Levels Measured Simultaneously in the Same Patients with Severe Systemic Inflammatory Response Syndrome and Severe Sepsis. Lung 2014; Jun;192(3):435-40. doi: 10.1007/s00408-014-9564-y
    **Nature of the claim: Similar device

  10. Maddirala S, Khan A, Optimizing Hemodynamic Support in Septic Shock Using Central and Mixed Venous Oxygen Saturation. Crit Care Clin 2010 Apr; 26(2):323-333. DOI:10.1016/j.ccc.2009.12.006
    **Nature of the claim: Similar device

  11. Pope JV et al. Multicenter Study of Central Venous Oxygen Saturation (ScvO2) as a Predictor of Mortality in Patients With Sepsis. Ann Emerg Med 2010; Jan;55(1):40-46.e1. DOI: 10.1016/j.annemergmed.2009.08.014
    **Nature of the claim: Similar device

  12. Nguyen HB et al. Implementation of a bundle of quality indicators for the early management of severe sepsis and septic shock is associated with decreased mortality. Crit Care Med 2007; Apr;35(4):1105-12. DOI: 10.1097/01.CCM.0000259463.33848.3D
    **Nature of the claim: Similar device

  13. Kortgen A et al. Implementation of an evidence-based “standard operating procedure” and outcome in septic shock. Crit Care Med 2006; Apr;34(4):943-9. DOI: 10.1097/01.CCM.0000206112.32673.D4
    **Nature of the claim: Similar device

  14. Bauer P, Reinhart K, Bauer, M. Early goal-directed therapy and outcome in septic shock. J Intensive Care 2007: 14, 87-92.
    **Nature of the claim: Similar device

  15. Chin KM et al. Central venous blood oxygen saturation monitoring in patients with chronic pulmonary arterial hypertension treated with continuous IV epoprostenol: correlation with measurements of hemodynamics and plasma brain natriuretic peptide levels. Chest 2007 Sep;132(3):786-92. DOI: 10.1378/chest.07-0694
    **Nature of the claim: Similar device

  16. Ander DS et al. Undetected cardiogenic shock in patients with congestive heart failure presenting to the emergency department. Am J Cardiol. 1998 Oct 1;82(7):888-91. DOI: 10.1016/s0002-9149(98)00497-4
    **Nature of the claim: Similar device

  17. Rivers EP et al. The clinical implications of continuous central venous oxygen saturation during human CPR. Ann Emerg Med 1992; Sep;21(9):1094-101. DOI: 10.1016/s0196-0644(05)80650-x
    **Nature of the claim: Similar device

  18. Csontos C et al. Arterial thermodilution in burn patients suggests a more rapid fluid administration during early resuscitation. Acta Anaesthesiol Scand 2008; Jul;52(6):742-9. DOI: 10.1111/j.1399-6576.2008.01658.x
    ***Nature of the claim: Own device

  19. Isaza-Restrepo A et al. Low values of central venous oxygen saturation (ScvO2) during surgery and anastomotic leak of abdominal trauma patients. World J Emerg Surg 2017; Jun 19;12:28. doi: 10.1186/s13017-017-0139-0
    ***Nature of the claim: Own device

  20. Scalea TM et al. Central venous oxygen saturation: a useful clinical tool in trauma patients. J Trauma 1990; Dec;30(12):1539-43.
    ***Nature of the claim: Own device

  21. Mikor A et al. Continuous central venous oxygen saturation assisted intraoperative hemodynamic management during major abdominal surgery: a randomized, controlled trial. BMC Anesthesiol 2015; Jun 4;15:82. doi: 10.1186/s12871-015-0064-2
    ***Nature of the claim: Own device

  22. Gasparovic et al. Diagnostic accuracy of central venous saturation in estimating mixed venous saturation is proportional to cardiac performance among cardiac surgical patients. J Crit Care 2014; Oct;29(5):828-34.
    DOI: 10.1016/j.jcrc.2014.04.012
    ***Nature of the claim: Own device

  23. Smetkin AA et al. Single transpulmonary thermodilution and continuous monitoring of central venous oxygen saturation during off-pump coronary surgery. Acta Anaesthesiol Scand 2009; Apr;53(4):505-14.
    DOI: 10.1111/j.1399-6576.2008.01855.x
    ***Nature of the claim: Own device

  24. Müller M et al. Continuous SvO2 measurement in infants undergoing congenital heart surgery--first clinical experiences with a new fiberoptic probe. Paediatr Anaesth. 2007 Jan;17(1):51-5. DOI: 10.1111/j.1460-9592.2006.02026.x
    ***Nature of the claim: Own device

  25. Jakob SM et al. Multicentre study on peri- and postoperative central venous oxygen saturation in high-risk surgical patients. Crit Care. 2006;10(6):R158.
    DOI: 10.1186/cc5094
    ***Nature of the claim: Own device

  26. Balzer F et al. High central venous saturation after cardiac surgery is associated with increased organ failure and long-term mortality: an observational cross-sectional study. Crit Care 2015; Apr 16;19:168. DOI: 10.1186/s13054-015-0889-6.
    ** Nature of the claim: Similar device

  27. Meguro M et al. Continuous monitoring of central venous oxygen saturation predicts postoperative liver dysfunction after liver resection. Surgery 2013; Aug;154(2):351-62. DOI: 10.1016/j.surg.2013.04.039
    ** Nature of the claim: Similar device

  28. Hu BY et al. Combined central venous oxygen saturation and lactate as markers of occult hypoperfusion and outcome following cardiac surgery. J Cardiothorac Vasc Anesth 2012; Feb;26(1):52-7. DOI: 10.1053/j.jvca.2011.07.021
    ** Nature of the claim: Similar device

  29. Nogueira PM et al. Central venous saturation: a prognostic tool in cardiac surgery patients. J Intensive Care Med 2010; Mar-Apr;25(2):111-6.
    DOI: 10.1177/0885066609355398
    ** Nature of the claim: Similar device

  30. Pearse R et al. Changes in central venous saturation after major surgery, and association with outcome. Crit Care. 2005;9(6):R694-9.
    DOI: 10.1186/cc3888 ** Nature of the claim: Similar device