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Applikon AppliSens sensors

Accurate measurements of your bioprocess

In the biotech- and pharmaceutical industry it is vital to have precise information about the process values of the bioprocess. These values directly affect viability, productivity, stability of the cells and influence the analysis of active ingredients. The AppliSens sensors are specifically designed for long-term, stable and accurate measurements in bioprocesses.

Contact us for more information

Your interest in bioreactor systems

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.  

Argentina

AP Biotech
Phone: +541142921611
Email: info@apbiotech.com.ar
URL: www.apbiotech.com.ar

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.  

Brazil

Sotelab
+55 (21) 3392-3563
www.sotelab.com.br

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.  

Chile, Peru

AP Bioprocess
www.ap-bioprocess.com

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

China

Applitech
Phone: +862034821111
Email: biotech@applitechpharma.com 
URL: www.applitechpharma.com

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Colombia

Intek Group
Phone: +57 316 3550400 - 749 8437
Email: contacto@intekgroup.com.co
URL: www.intekgroup.com.co

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Czech Republic

Vekamaf
Phone: +420 284 690 881
URL: www.vekamaf.cz

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Denmark

Holm & Halby
Phone: +454326 9400
Email: info@holm-halby.dk
URL: www.holm-halby.dk

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Estonia

Bio Techa
Phone: +372 6597101
Email: info@biotecha.ee
URL: www.biotecha.lt

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Hungary

Holimex
Phone: +36 1 391 4400
URL: www.holimex.hu

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

India

Spinco Biotech Pvt. Ltd.
Phone: +91 44 45678900
Email: info@spincotech.com
URL: www.spincotech.com

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Indonesia

PT Arico Sainsindo Nusantara
Phone: +62-21 580 6342 / 3
Email: arico@dnet.net.id
URL: www.ptarico.com

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.  

Ireland

Asistec
Phone: +353(0)1286 8796
Email: info@asistec.ie
URL: www.asistec.ie

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Israel

Medent Group
Phone: +97286237984
Email: info@medent.co.il
URL: medent.co.il

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Italy

Steroglass
Phone: +39 075 609091
Email: info@steroglass.it 
URL: www.steroglass.it

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Japan

Sanyo Trading Co., LTD
Phone: +81-3-3518-1196
URL: www.sanyo-trading.co.jp

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Lithuania

Bio Techa
Phone: +370 5 237 60 07
Email: info@biotecha.lt
URL: www.biotecha.lt

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Norway

Bio Nordica
Phone: 23 03 58 00
Email: info@bionordika.no
URL: bionordika.no

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Poland

Labo Baza
Phone: +4861 812 57 45
Email: biuro@labobaza.pl
URL: www.labobaza.pl

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Russia

Abtek
Phone: +7(495) 723-64-97
Email: abtek@abtek.ru
URL: abtek.ru

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Singapore

Zil Sci Pte. Ltd.
Phone: +65 6767 2929
Email: ENQUIRY@ZILSCI.COM
URL: www.zilsci.com

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Slovakia

Vekamaf
Phone: +421-2-52932891
URL: www.vekamaf.cz

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

South Africa

Seperations
Phone: +27 11 919 1000
Email: info@separations.co.za
URL: separations.co.za

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

South Korea

SeouLin Bioscience
Phone: +821670-5911
Email: support@seoulin.co.kr
URL: www.seoulin.co.kr

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Switzerland

Resea Biotec
Phone: +41 34 531 08 20
Email: office@reseabiotec.ch
URL: www.reseabiotec.ch

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Taiwan

Tseng Hsiang Life Science Ltd.
Phone: +862-27851156
Email: info@thco.com.tw
URL: www.thco.com.tw

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Meditop Co., Ltd

Holm & Halby
Phone: +662 9331133
Email: info@meditopthailand.com
URL: meditopthailand.com

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Turkey

Ant Teknik
Phone: +90 216 422 6700
Email: antteknik@antteknik.com 
URL: www.antteknik.com

Continuous measurement of parameters enable process optimization and product yield maximization

  • Stable signal over longer time
  • Easy calibration and short response time
  • Low sensitivity to fouling and thus drifting

Proper control of a bioprocess requires reliable monitoring of many process parameters. From basic physiochemical properties such as pH or dissolved oxygen to determination of biomass density or metabolite concentrations, Getinge offers several process analytical technologies (PAT) for making sophisticated measurements of your bioprocess.

Optical DO: LumiSens

  • Reduced maintenance costs
  • Longer sensor life time due to two-part design
  • Direct use after autoclaving as no polarization is needed

The Applikon LumiSens sensor can be used right after autoclaving. Polarization is no longer needed, compared to the traditional polarographic DO2 sensors, and the need for calibration is significantly decreased to only once per year instead of calibrating for every run. The electrolyte and membranes don't need replacement, reducing maintenance costs. The RedFlash optical technology allows accurate measurements especially in the low oxygen concentration range where classic probes are less accurate. The smart sensor design separates the electronics from the glass sensor part, guaranteeing a long sensor life with repeated sterilizations.

AppliSens DO2 sensors

DO2 Sensors

  • Easy calibration
  • Low drift by usage of titanium and PEEK material
  • Optimal cleanability due to fully electro-polished surface

Measurements of dissolved oxygen (DO2) in biotechnological processes is a basis for process optimization and maximization of the product yield. A microorganism or cell responds to the oxygen concentration in regulating its overall metabolism. Therefore, knowledge of the DO2 concentration and its proper control during the process are of great importance. The AppliSens DO2-sensor is specifically designed for long-term, stable and accurate measurements in bioprocesses. The DO2-sensor has a titanium membrane module to minimize the measurement drift.

AppliSens pH sensors

pH Sensors

  • Accurate measurement
  • Stable signal over longer time
  • Low sensitivity to fouling and thus drifting due to sleeve diaphragm

Within upstream bioprocessing it is vital to have precise information about the pH value of the bioprocess. The pH level directly affects viability, productivity, and stability of the cells and it influences the analysis of active ingredients. The AppliSens pH+ sensor has a fixed sleeve diaphragm that reduces the influence of the culture medium on the pH measurement. Compared to classic diaphragm types, this sleeve diaphragm increases measuring accuracy and the lifetime of the sensor which is vital for long lasting biotech cultivation processes.

RedOx Sensors

  • Accurate measurement
  • Short response time
  • Stable signal over longer time



The RedOx potential (Reduction / Oxidation) of a bioreactor culture can be measured using a RedOx sensor. The value of the reading of the sensor can depend on pH, growth phase, growth medium components, and fermentation  endproducts (especially fermentation acids and hydrogen). RedOx measurement is also used in anaerobic fermentations as an alternative to the Dissolved Oxygen sensor which does not give much process information in anaerobic situations.

Applicable for cGMP applications

The AppliSens sensors consist of FDA approved materials which make them cGMP compatible. They withstand repeated sterilize-in-place (SIP) and clean-in-place (CIP) cycles.

Compact design of sensor and sensor head

The AppliSens sensors have a robust design using a tempered glass shaft. The sensor heads occupy minimal space on the bioreactor top plate allowing easy set up.

Interchangeable with other brands

The AppliSens sensors come with a standardized PG 13.5 connection, which guarantees interchangeability with other bioreactor brands. Freedom of choice.

LumiSens Optical DO Sensors Specifications

Physical characteristics  
Diameter (mm) 8
Insertion length (mm) 115, 135, 185
Cable connection USB-A
Measurement range temperature 0 – 70 °C
Measurement range 0 - 250% (Air), 0 - 50% (Oxygen)
Glass tube life time Minimum 20 autoclave cycles
Measurement principle Optical
Sensor connection Magnetic
Signal Digital

 

DO2 Sensors Specifications

Physical characteristics  
Diameter (mm) 12
Insertion length (mm) 70, 110, 235, 325, 425, 590
Diameter for mini bioreactor (mm) 8
Insertion length for mini bioreactor (mm) 150, 170
Sensor connection K9
Signal Analog nA
Drift <2% per week

 

pH Sensors Specifications

Physical characteristics  
Diameter (mm) 12
Length (mm) 120, 235, 325, 425, 590
Diameter for mini bioreactor (mm) 8
Length for mini bioreactor (mm) 115, 135, 185
Sensor connection K9
Communication type Analog mV
Measurement range (pH) 0 - 12

RedOx Sensors Specifications

Physical characteristics  
Diameter (mm) 12
Length (mm) 120, 235, 325
Diameter for mini bioreactor (mm) 8
Length for mini bioreactor (mm) 115, 135, 185
Sensor connection K9
Communication type Analog mV